Mainly due to diabetic foot disease caused by acral arteries and microvascular ischemia, hypoxia, organizations lose their vitality, coupled with neuropathy partial loss of consciousness, easy to damage, caused by infection. The disease pathology is mainly arteries and small arteries atherosclerosis, microcirculation disorder, affecting the absorption of nutrients and metabolic products of exclusion, resulting in acral ischemia, hypoxia, nutrition barriers, partial loss of vitality. Coupled with decreased resistance neuropathy, pain, temperature sense obstacles or disappeared, resulting in serious injury, ulcers, gangrene and infection, Shenzhe need amputation. In short, the disease was mainly due to arterial and microvascular disease caused by acral ischemia, hypoxia, organizations lose their vitality, coupled with neuropathy partial loss of consciousness, easy to damage, caused by infection.
1, arterial blood vessel blockage: Diabetes prone to atherosclerosis, so that the lumen of blood vessels arteries blocked, resulting in acral ischemia and hypoxia, diabetes gangrene. The reasons are: (1) hyperinsulinemia, in particular Type II diabetes, obesity, physical person, often tend to hyperinsulinemia. Cause fat metabolism disorders, induction and activation of fatty synthase, so that an increase in fat synthesis, very low density lipoprotein increased significantly, resulting in hyperlipoproteinemia and promote lipid deposition and smooth muscle cell proliferation, thereby causing atherosclerosis.
(2), platelet dysfunction, txa2 synthesis increased arterial intima damaged office pgl2 synthase is a lack of, pgl2 synthesis reduced enhanced platelet aggregation, blood vessels tend to spasm, contributed to the occurrence of arterial disease and partial blockage of blood vessels.
(3) endothelial cell injury due to genetic defects, easy to damage and necrosis. Hyperglycemia lead to damage and necrosis, arterial endothelial cell damage, the generation and destruction of clotting factors often out of balance, resulting in hardening of arteries and blocking blood vessels.
2, microvascular basement membrane thickening
Diabetic gangrene and microvascular lesions, basement membrane thickening are closely related. Microangiopathy in human weight-bearing area is particularly notable. As the capillary basement membrane thickening, causing fluid and protein leakage, resulting in swollen feet and prevent white blood cells into the cell, reducing the ability of local organizations, anti-infective, white energy increased fibrin activity reduced the formation of micro-thrombosis increase the local tissue ischemia necrosis, resulting in ulceration gangrene, wound long treatment.
Microvascular basement membrane thickening in diabetes, it is also accompanied by changes in the chemical structure of basement membrane thickening, sugar increased significantly, protein and fat reduced, with the exception of people with diabetes, age, duration, and the lack of insulin and other factors, the partial tissue hypoxia leading to the direct cause of diabetic microangiopathy, leading to local tissue hypoxia of the following factors:
(1) abnormal hemorheology and plasma fibrinogen in acute stress, beads globulin, a, acid glycoprotein was significantly higher and so on to promote the increased whole blood viscosity and erythrocyte aggregation, microvascular perfusion disorders.
(2) The mechanism of blood coagulation disorders, diabetes patients from Ⅷ, the first Ⅹ coagulation factors and fibrinogen were higher, fibrin activity to reduce the influence local tissue oxygen supply. Enhanced platelet aggregation, microcirculation blocked, increased local tissue hypoxia.
(3) an increase in glycated hemoglobin, glycated hemoglobin, or fast normal hemoglobin 7% of total hemoglobin, diabetes, glycosylated hemoglobin synthesis increased about 2-3 times the normal. Very difficult to break down, resulting in separation of oxygen reduction in tissue hypoxia.
(4) angiotensin-converting enzyme activity increased serum angiotensin-converting enzyme was significantly increased, microvascular disease, angiotensin-converting enzyme values higher, suggesting that diabetes in the blood vessels leading to tissue hypoxia spasticity.
3, diabetic neuropathy: diabetes mellitus complicated by vascular disease when associated with peripheral neuropathy and nerve of plant diseases, peripheral nerves leading to sensory and motor neurological disorders, muscle atrophy, skeletal deformities, pain, temperature sense weakened or disappeared, is trauma or self - organization to undermine the infected wound. Autonomic neuropathy leading to reduced sweating, dry skin vasomotor dysfunction, tissue ischemia and embrittlement infected necrosis. The presence of neuropathy the body of local organizations often exposed to danger, experienced trauma can lead to gangrene, diabetic neuropathy and diabetic vascular disease interaction, mutual influence of the gangrene infection increase the local tissue.
4, infection factors: a good diabetic patients uncontrolled host defense mechanism weakened response to the invasion of micro-organisms were inhibited at all stages, including the role and chemical toxins, phagocytic white blood cells, bactericidal effect of serum coherent factors and the role of cellular immunity , easy to infection, once infected, sicker. Due to neuropathy, acral sensory dysfunction, were infected with injuries. Diabetic microangiopathy to local tissue hypoxia is conducive to the growth of anaerobic bacteria to change the white blood oxygen dependent bactericidal effect, once infected, the ability to enhance platelet adhesion, fibrin activity increased, soluble fibrin activity reduced the formation of micro-thrombosis and increase the local tissue ischemic necrosis.
Diabetic gangrene is a traditional Chinese medicine, "Diabetes", "Pulse Bi", "anthrax" and other areas. Chinese medicine treatment of this disease has a long history and accumulated a lot of valuable experience in medicine that the pathogenesis of this disease is mainly Diabetes drag on, Qi and Yin Deficiency, meridians Stagnation, blood lines impeded, acral dystrophy, combined with hot and humid the next Note, heat sera stasis, made pulse weakness, anthrax. Elements found in modern medical research, diabetes, human memory, there is the unusual lack of zinc, zinc deficiency after wound healing is slow, prone to infection and organizations, liquefaction, is the main reason for diabetes, ulcers implemented. A large number of clinical studies have shown that zinc treatment can significantly speed up the wound healing. So we used the treatment of qi Yin, clearing away heat dampness, activating blood detoxification methods such as, dialectical therapy, family medicine recipe "sugar more side" with the elements of special hypoglycemic hypoglycemic agents plus zinc therapy received a significant effect, generally 30 days, significantly effective, basically cured within 90 days. Not only the wound can be healed, and physical body condition were significantly improved, showing a great advantage, particularly in wet lower extremity ulcer was unique, an average of 30 days can be healed by the medical profession of today's great concern.
